Results : 5 1 , a member of the integrin family , has strong correlation with tumorigenicity , development and metastasis 结果： 5 1是整合素家族的一员，参与肿瘤的发生、发展与转移。
Besides morphologic changes , biological moecules including fgf10 , integrin , egf , tgf play an important role in the process of eyelids ' reseperation 除了形态学上的变化外，表皮生长因子( egf ) 、转化生长因子( tgf ) 、整合素等生物大分子也参与眼睑的分离过程。
Our previous data suggested that the a , p 3 integrin - like proteins be present in lily pollen tube and mediate the interaction between pollen and extracellular matrix of pistil to regulate pollen tube growth 我室前期工作表明，百合花粉管质膜上存在类整合素、 3 ，并可能通过介导花粉管与雌蕊基质间的相互作用调节花粉管的生长。
Being a kind of adhesion molecules associating cells with extracellular matrix , integrins play a variety of roles in the process of invasion and metastasis in pancreatic adenocarcinoma 胰腺癌手术切除率低死亡率高的重要原因之一是肿瘤早期即能发生局部浸润和远处器官转移，整合素作为细胞与细胞外基质的黏附分子，在胰腺癌侵袭及转移过程中发挥多重作用。
The basement membrane proteins including laminin , type iv collagen , type vii collagen , integrin a6 , and integrin b4 were all detected at the dermal ? epidermal junction , which showed a continuous structure in the 4 weeks after grafting 移植后4周，在真皮、表皮交界的基底膜带检测到的基底膜蛋白包括有层粘连蛋白，型胶原，型胶原， 4和6整合素，表明是一个连续生长的过程。
Based on the " self - migrating and surface - segregation " behavior , the amphiphile segregation surface was therefore constructed on hydrophobic pdl - la matrix , which containing the structure of peo spacer combining cell adhesion ligands to mimic the extracellular matrix ( ecm ) 基于两亲共聚物在疏水高聚物材料内的自迁移和表面富集行为，在聚乳酸材料上构建了以peo桥联氨基酸或整合素配体多肽片段的类细胞外基质表面。
To elucidate further the presense and function of integrin - like protein , we try to clone 3 " terminus seqence of integrin - like gene from germinated pollen of lily by 3 " race using degenerate primers corresponding to the conserved cytoplasmic regions of a and 3 subunits 而要进一步从分子水平上证实类整合素的存在以及研究它的功能，必须克隆其基因。根据动物整合素、亚基的胞质域保守序列设计简并引物，利用3 race的方法扩增、亚基的3末端序列。
Meanwhile , the male mice deficient for germ - cell cyritestin are infertile . therefore , both spl7 and cyritestin are important molecules in the process of fertilization . nevertheless , people can not get fully satisfied the results in some contraceptive researches for their limited effects respectively 其n端含有去整合素结构域，然而多数实验结果表明单一应用这些分子所获得的免疫性避孕效应非常有限，从而提出今后的研究方向是更具抗原性或良好运载体系的新型多价疫苗。
The identified proteins are involved in a variety of cellular process including several zinc finger proteins relevant to transcription regulation , such as zinc finger 198 , 263 , 14 , 224 , zf6 , novel protein similar to transcriptional represser ctcf , and kruppel - like zinc finger protein ; two members of the adams ( a disintegrin and metalloprotease domain ) family ; two members of integrin family ; several proteins involved in the signal transduction , cell - cycle control , chromatin remodeling and transcription repression ; and also some proteins of cell skeleton and some with unknown functions 鉴定出的蛋白包括多个与转录调控相关的锌指蛋白，如锌指蛋白198 、 263 、 14 、 224 、 zf6 、转录抑制因子ctcf样蛋白、幻肚pple样锌指蛋白等:两个含金属蛋白酶结构域和整合素结合结构域的家族成员adam28和adam17 ;两个整合素家族成员pz整合素和含十个egf样结构域的整合素( tied ) ;与细胞信号转导通路有关的蛋白;与细胞周期调控有关的蛋白;与染色体重塑和基因转录抑制有关的蛋白;细胞骨架蛋白以及其他功能未明的蛋白等。
The study of in - situ construction of cytocompatible surface on pdl - la matrix via amphiphile - amino acid ( rgd ) hybrid self - segregation - the amphiphilic diblock copolymer , poly ( dl - lactide ) - poly ( ethylene oxide ) ( pla - peo ) copolymer , containing hydrophobic pla block and hydrophilic peo block was synthesized via coupling method in this dissertation . cell - adhesion - promoting amino acids and integrin receptor peptide rgd were then immobilized at the end of peo chain of pla - peo copolymer via hydroxyl group activation technique . the solvent blending and casting method was then used to obtain the amphiphile modified pdl - la membranes 两亲共聚物-氨基酸( rgd )杂化体原位自修饰构建聚乳酸细胞相容性表面的研究一本论文首先设计并合成了一类含疏水聚乳酸( pla )链段和亲水聚氧乙烯( peo )链段的两亲嵌段共聚物材料( pla - peo ) ，利用peo链端的活性官能团羟基固定了促细胞粘附的氨基酸及整合素配体多肽片段rgd 。
