Elevation of intracellular calcium ions may be partly induced by increased influx through sarcolemma l type - calcium channels . intracellular calcium elevation , on one hand , would activate calpain , a calcium - dependent cysteine protease that degrade the myofibrillar proteins and cause muscle atrophy ; on the other hand , result in activation of calcineurin which enhance the activity of mhc i promoter and inhibit a shift of mhc isoforms from slow to fast in soleus 这样，可能使得萎缩比目鱼肌细胞内钙离子水平升高，细胞内钙离子静息浓度的增加一方面激活calpain ，增加收缩蛋白的降解，使肌肉萎缩；草四军医大月卜祠成士学位论文另一方面通过激活钙调神经磷酸酶，增加快型mhc基因的表达，使骨骼肌肌球蛋白重链( mhc )发生由慢型向快型的转化。
The pharmacology analysis on the increased current in the single mutant ( sos3 / athkt1 ) indicated that the increased current , possibly contributed by athktl activity , could be inhibited by ttx and ca2 + . it is insensitive to tea * and have the same selectivity to li + . the data suggest that the protein athktl perhaps is a na + - permeable channel 结果显示athkt1蛋白介导的电流增大可被ttx和ca ~ ( 2 + )部分抑制，对k ~ +通道抑制剂tea ~ +不敏感，而，盯甫大月卜二几月目睁困月周口创七掩呀，匕月目卜位伦大且对li +有相似的选择性，表明athkti蛋白可能为一种na +通透型阳离子通道，其蛋白活性受到5053蛋白的抑制调节。
