口服疫苗

• For those reasons , the use of vaccines for treatment and prevention of h . pylori infection has been explored
  而以减毒鼠伤寒沙门氏菌作为口服疫苗载体的h pylori疫苗由于其许多优点而倍受瞩目。
• Also , in the case of rotavirus , oral vaccines would prompt an immune response where it is most desirable ? in the gastrointestinal tract
  对轮状病毒来说，口服疫苗也能够让疫苗在最适当的位置，也就是胃肠道，引发免疫反应。
• The oral vaccine works because the ingestion of live virus mimics the natural process of infection , encouraging the production of antibodies in the gut
  口服疫苗能够发挥效力是因为活病毒在机体吞入后可模拟天然感染过程，同时刺激消化道产生抗体。
• Transgenic plants , as a vaccine source , have several advantages in which they are relatively inexpensive , safe and can be adminstrated orally
  同时植物细胞还是一种理想的口服疫苗保护载体，在其中表达的抗原蛋白甚至无须纯化，可以直接口服免疫。
• The reason of such difference is not clear at present and may relate to the low level of antigen expression in lactobacillus , which suggests that it is necessary to select diff erent strains of lab and match different expression vectors as oral vaccine vehicles
  这种不同的原因目前仍然不清楚，可能与抗原在乳杆菌中低水平表达有关。这暗示筛选不同的乳酸菌菌株作为口服疫苗载体和匹配不同的表达载体的必要性。
• Although different approaches to vaccines have been considered ? human versus animal strains , live versus killed viruses , whole virus or protein subunits ? rotavirus researchers followed the lead of albert sabin , creator of the oral poliomyelitis vaccine
  疫苗的制作有好几种不同的方式，包括使用人类或动物的病毒品系、活病毒或死病毒、全病毒或蛋白质次单位等；经过考量后，轮状病毒研究人员决定采用小儿麻痹口服疫苗发明人沙宾的做法。
• Antigens from infectious bacterial or viral diseases have been introduced into plants . so introducing vp7 gene into tomato to develop edible plant vaccine of rotaviruses would change the traditional means of production of vaccines and the cost of vaccine production would be reduced greatly
  因此，将vp7基因导入番茄，获得具有免疫原性的轮状病毒植物口服疫苗，将为防治轮状病毒引起的小儿腹泻提供新型疫苗，具有潜在的社会和经济意义。
• Compared with lactococcus , lactobacillus is the better choice of oral vaccine for some properties , including their immunogenicities , resistance to the circumstance of the alimentary tract and remaining in long period in gastro - intestinal tract , however , lactococcus is more effective in selecting antigen to induce immunological response , while the positive result of lactobacillus is limited
  与乳酸乳球菌相比，乳酸杆菌特有的一些性质使其成为口服疫苗更好的选择，这些特性包括它们的免疫原性，对上消化道内情况的耐受以及能在胃肠道中长时间留存，然而乳球菌在选择抗原诱导免疫反应方面更加有效，但是乳杆菌的阳性结果十分有限。
• Most lactic acid bacteria ( lab ) are commonly considered as safe probiotics . some strains of lactic acid bacteria are found to have the ability to adhere and live in the gastro - intestinal tract , urinogenital system or mucosa with no contemporary immunogenicity . importance is widely attached to the research of the lab as live oral and mucosal vaccine
  大部分乳酸菌是普遍认为安全的益生菌，利用一些乳酸菌可以在胃肠道、泌尿、生殖系统中或粘膜部位粘附存活且无病原性等特点，开展乳酸菌作为活菌口服疫苗或粘膜疫苗载体的研究受到了广泛的重视。