It is well known that tumor necrosis factor a ( tnfa ) can play very different character in defence mechnism of body and pathologic injury , in which it can inhibit or kill tumor cell , and induce inflammation against infection ; on the other hand , tnfa can be as a very important mediator to cause some serious pathologic processes such as septic shock , gvhr and some autoimmune diseases 肿瘤坏死因子( tumornecrosisfactor ， tnf )具有对某些恶性肿瘤的抑制或杀伤作用，也是致内毒素性休克、急性移植物抗宿主病及一些自身免疫病的重要效应因子，因此tnf的改造和tnf拮抗剂的研究受到各国学者的重视。
