To further evaluate the relationship of early atherosclerosis and modern life - styles , the research group arranged dietary modification emphasising on reduced total calorie intake , less meat protein , fat and complex carbohydrate , and a structured exercise training programme for the obese children , each session for 90 minutes , for 3 times a week 在成年人中，由于高血压、脂肪代谢紊乱等多种因素的相互影响，很难评估肥胖对心血管粥样硬化性疾病的直接危害关系，但在儿童时期进行检测，就可剔除上述的多种其他因素。
The following research areas will be involved in the project : ( 1 ) mechanism of hereditic factors and its function in chinese type 2 diabetes ; ( 2 ) metabolomics on the cell stress and its nutrition intervention in the type 2 diabetes ; ( 3 ) mechanisms of metabolic nuclear receptors in the process of insulin resistance and type 2 diabetes onset ; ( 4 ) roles of signal transduction molecules , lipid metabolic disorder to insulin resistance ; ( 5 ) type 2 diabetes development and role of pathological changes of blood vessels ; ( 6 ) abnormal insulin secretion , apoptosis and type 2 diabetes ; ( 7 ) function of molecular network of type 2 diabetes progression 本项目拟开展以下研究工作： （ 1 ）中国人2型糖尿病发生过程中遗传因素的发现及其作用机制； （ 2 ）细胞应激在中国人2型糖尿病发生过程中的作用机制及其营养干预的代谢组学； （ 3 ）代谢性核受体在胰岛素抵抗和2型糖尿病发病中的作用机制； （ 4 ）细胞信号转导分子、脂代谢紊乱与胰岛素抵抗的关系； （ 5 ） 2型糖尿病发展过程与血管病变； （ 6 ）胰岛素分泌异常、细胞凋亡与2型糖尿病； （ 7 ） 2型糖尿病发生过程中的分子网络与作用机制。
" endothelial vasodilator dysfunction and carotid intima - media thickening are the early markers of arteriosclerosis , " explained professor woo . " in adult obesity , there are many other risk factors such as hypertension and abnormality in lipids metabolism , it is very difficult to delineate the direct effect of obesity to vascular changes . however , it may be easier in children when we can avoid the interference of other risk factors and more precisely isolate the effect of obesity . 血管内皮功能障碍和颈动脉内中膜增厚是反映血管粥样硬化的早期指标；在成年人中，由于与肥胖并存高血压、脂肪代谢紊乱等多种因素的相互影响，很难评估肥胖对心血管粥样硬化性疾病的直接危害关系；在儿童时期进行检测，就可避开上述的多种其他因素的干扰，更准确地预测出单纯肥胖对血管硬化的影响。
The diabetes coronary heart disease high reason of incidence of a disease is many - sided , yet chiefly is the fat supersession chaos , and creates glycerine three grease and the cholesterol to get higher , that sweet and protein are metabolized oddly be able to create myocardium capillary pathological changes and the myocardium supersession chaos , but the flora nervous system chaos easily arouses that blood vessel pulling force adds and injures the artery breastwork 糖尿病冠心病发病率高的原因是多方面的，但主要是脂肪代谢紊乱，造成甘油三脂和胆固醇增高，糖和蛋白质代谢的失常会造成心肌的微血管病变和心肌代谢紊乱,而植物神经系统紊乱易引起血管张力增加而损伤动脉壁。
