full agonist造句

• A characteristic that distinguishes these substances from pure ER agonists and antagonists ( that is, full agonists and silent antagonists ) is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues.
• "' E-55888 "'is a drug developed by Esteve, which acts as a potent and selective full agonist at the hyperalgesic but not analgesic, but when administered alongside morphine, E-55888 was found to significantly increase the analgesic effects.
• "' Proxyfan "'is a histamine H 3 receptor ligand which is a " protean agonist ", producing different effects ranging from full agonist, to antagonist, to inverse agonist in different tissues, depending on the level of constitutive activity of the histamine H 3 receptor.
• "' CI-966 "'( developmental code name ) is a central nervous system depressant acting as a GABA reuptake inhibitor, specifically a highly potent and selective IC 50 = 0.26 礛 ), and hence indirect and non-selective GABA receptor full agonist.
• "' PNU-22394 "'is a drug which acts as an agonist at serotonin 5-HT 2 5-HT 2B, although it is only a full agonist at 5-HT 2C, but partial agonist at 5-HT 2A and 5-HT 2B.
• It has nootropic, anorectic, rewarding and antiparkinsonian effects in animal studies, but its high potency and long duration of action causes D 1 receptor downregulation and tachyphylaxis, and unlike other D 1 full agonists such as SKF-82, 958, it does not produce place preference in animals.
• MDMB-CHMICA acts as a highly potent full agonist of the EC 50 value of 0.14 nM, which is approximately 8 times lower than the EC 50 of JWH-018 ( 1.13 nM ) and twofold lower than AB-CHMINACA ( 0.27 nM ).
• "' NM-2201 "'( also known as "'CBL-2201 "') is an indole-based synthetic cannabinoid that presumably has similar properties to the closely related 5F-PB-22 and NNE1, which are both full agonists and affinity.
• SKF-82, 958 and similar D 1-like-selective full agonists like SKF-81, 297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine.
• This produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent ?-opioid full agonist in regard to some effects such as analgesia, a ceiling effect is seen on other effects such as constipation and respiratory depression which is believed to involve interaction with the ?-opioid receptor