factor v leiden造句

• Behind non-O blood type and factor V Leiden, prothrombin G20210A is one of the most common genetic risk factors for VTE . It was realized in 1996 that a particular change in the genetic code produces the body to make too much of the prothrombin protein.
• Considering that the risk of developing an abnormal blood clot averages about 1 in 1, 000 per year in the general population, the presence of one copy of the factor V Leiden mutation increases that risk to between 4 in 1, 000 to 8 in 1, 000.
• Because the risks of warfarin  which is used to treat blood clots  in a relatively young and otherwise healthy population are low, while the risk of adverse physical and psychological outcomes for untreated transgender patients is high, pro-thrombotic mutations ( such as factor V Leiden, S deficiency ) are not absolute contraindications for hormonal therapy.
• Many studies had previously indicated that many people with thrombosis showed resistance activated protein C . In 1994 a group in Leiden, The Netherlands, identified the most common underlying defect a mutation in factor V that made it resistant to the action of activated protein C . The defect was called " factor V Leiden ", as genetic abnormalities are typically named after the place where they are discovered.