x inactivation造句

• X inactivation plays a key role in dosage compensation mechanisms that allow for equal expression of the X and autosomal chromosomes.
• This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
• Women have a predisposition towards the condition and research indicates that this might in part be due to Skewed X inactivation.
• Xist is expressed from one of the X chromosomes in females and serves to inactivate the other X chromosome during X inactivation.
• Males with Klinefelter syndrome, who have an extra X chromosome, will also undergo X inactivation to have only one completely active X chromosome.
• X inactivation allows for equal dosage of X-linked genes for both males and females by inactivating the extra X chromosome in the females.
• The Xist RNA gene consists of an Xist Inactivation Center ( XIC ), which plays a major role in Xist expression and X inactivation.
• This gene lies within the male specific region of chromosome X ( thymosin beta-4 ) escapes X inactivation and encodes an actin sequestering protein.
• In mammals with more than one X chromosome, the genes on all but one X chromosome are not expressed; this is known as X inactivation.
• The mosaic pattern of X inactivation may also determine how penetrant a disease is, if the disease allele is present on one X-chromosome and not the other.
• Since females operate on only one of their two X chromosomes ( X inactivation ) a female carrier may or may not manifest symptoms of the disease.
• Her lab has worked on one of the mouse mutants identified in the mutagenesis screen, identifying a critical role for the protein Smchd1 in X inactivation in cancer.
• This is because of the chance that there will be a skewed X inactivation pattern enzyme measurement in fibroblasts, meaning that the enzyme activity measurement may not be entirely accurate.
• In calico cats the mosaic pattern of X inactivation is easily seen because a gene affecting coat color is carried on the X, resulting in patches of color on the coat.
• MACROH2A deposition has been suggested to be regulated by the CULLIN3-SPOP-RBX1 ligase complex and is actively involved in stable X inactivation, likely through the formation of an additional layer of epigenetic silencing.
• When both alleles of Tsix are null ( homozygous mutant ), the results are low fertility, lower proportion of female births and a reversion to random X inactivation rather than gene imprinting.
• Some methods involved in dosage compensation to inactivate one of the X chromosomes from one of the sexes are Tsix antisense gene, DNA methylation and DNA acetylation; however, the definite mechanism of X inactivation is still poorly understood.
• The center contains twelve genes, seven of which code for proteins, five for untranslated RNAs, of which only two are known to play an active role in the X inactivation process, " Xist " and " Tsix ".
• Although it was known that certain Xi histone methylation markings stayed relatively constant between species, it has recently been discovered that different organisms and even different cells within a single organism can have different markings for their X inactivation.
• Females possess two X-chromosomes, males have one X and one X-linked recessive, a female carrying the defect on one of her X-chromosomes may not be affected by it, as the equivalent allele on her other chromosome should express itself to produce the necessary clotting factors, due to X inactivation.